Pak1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comPak1 Polyclonal Antibody for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Pak1(Gene name) > Mouse

Pak1 (Gene name),

Serine/threonine-protein kinase PAK 1 (Protein name ), PAK1_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Pak1(Paka);

Protein name:

Serine/threonine-protein kinase PAK 1;

Alternative:

CDC42/RAC effector kinase PAK-A;Alpha-PAK;p65-PAK;p21-activated kinase 1(PAK-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer in its autoinhibited state. Active as monomer. Interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. Binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. Interacts with ARHGEF7. Also interacts with CRIPAK. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM (via cytoplasmic domain); the interaction is direct and enhanced in presence of RAC1 (By similarity). Interacts with DSCAM and NISCH. Interacts with SCRIB.

Function:

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

545

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

545:

CLEMDVEKRG | SAKELLQHQF | LKIAKPLSSL | TPLMHAAKEA | TKNNH

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Mm.260227

Pfam:

PF00786

String:

O88643

SMR:

O88643

STRING:

10090.ENSMUSP00000033040

Uniprot:

O88643

FOR

ELISA Kit for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

E13344m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

E13344r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

E13344h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

E13344b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

U13344m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

U13344r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

U13344h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

U13344b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

P13344Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

P13344Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Serine/threonine-protein kinase PAK 1

Cat.:

P13344Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Serine/threonine-protein kinase PAK 1

Protein for Mouse Serine/threonine-protein kinase PAK 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes."
Burbelo P.D. , Kozak C.A. , Finegold A.A. , Hall A. , Pirone D.M.
Gene232:209-215(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Lubec G. , Sunyer B. , Chen W.-Q.
Submitted (2009-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 204-215; 276-299; 309-320; 372-388 AND 472-489;IDENTIFICATION BY MASS SPECTROMETRY
strain: OF1.
tissue: Hippocampus.
3.

"p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis."
Schurmann A. , Mooney A.F. , Sanders L.C. , Sells M.A. , Wang H.G. , Reed J.C. , Bokoch G.M.
Mol. Cell. Biol.20:453-461(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"Pak1 phosphorylation on T212 affects microtubules in cells undergoing mitosis."
Banerjee M. , Worth D. , Prowse D.M. , Nikolic M.
Curr. Biol.12:1233-1239(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-212
5.

"Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1."
Luo Z.G. , Wang Q. , Zhou J.Z. , Wang J. , Luo Z. , Liu M. , He X. , Wynshaw-Boris A. , Xiong W.C. , Lu B. , Mei L.
Neuron35:489-505(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEUROMUSCULAR JUNCTION DEVELOPMENT;INTERACTION WITH DVL1 AND MUSK
6.

"The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK."
Alahari S.K. , Reddig P.J. , Juliano R.L.
EMBO J.23:2777-2788(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NISCH
7.

"The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak."
Li W. , Guan K.L.
J. Biol. Chem.279:32824-32831(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSCAM
8.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
9.

"Scrib regulates PAK activity during the cell migration process."
Nola S. , Sebbagh M. , Marchetto S. , Osmani N. , Nourry C. , Audebert S. , Navarro C. , Rachel R. , Montcouquiol M. , Sans N. , Etienne-Manneville S. , Borg J.-P. , Santoni M.-J.
Hum. Mol. Genet.17:3552-3565(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCRIB
10.

"Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic beta-Cells."
Nie J. , Sun C. , Faruque O. , Ye G. , Li J. , Liang Q. , Chang Z. , Yang W. , Han X. , Shi Y.
J. Biol. Chem.287:26435-26444(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BRSK2;PHOSPHORYLATION AT THR-423
11.

"Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6."
Borroni E.M. , Cancellieri C. , Vacchini A. , Benureau Y. , Lagane B. , Bachelerie F. , Arenzana-Seisdedos F. , Mizuno K. , Mantovani A. , Bonecchi R. , Locati M.
Sci. Signal.6:RA30-RA30(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION

Product Feedback Wall

* Email:
*Comments: